Surgical Stress Promotes Tumor Progression: A Focus on the Impact of the Immune Response.

ABSTRACT: Despite advances in systemic therapies, surgery is crucial for the management of solid malignancy. There is increasing evidence suggesting that the body's response to surgical stress resulting from tumor resection has direct effects on tumor cells or can alter the tumor microenvironment. Surgery can lead to the activation of early and key components of the innate and adaptative immune systems. Platelet activation and the subsequent pro-coagulation state can accelerate the growth of micrometastases. Neutrophil extracellular traps (NETs), an extracellular network of DNA released by neutrophils in response to inflammation, promote the adhesion of circulating tumor cells and the growth of existing micrometastatic disease. In addition, the immune response following cancer surgery can modulate t

SUBMITTER: Onuma AE 

PROVIDER: S-EPMC7766515 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature