The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3.

ABSTRACT: Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity. PON1 and its isoforms play an important role in drug metabolism as well as in the prevention of cardiovascular and neurodegenerative diseases. Although all three members of the PON family have the same origin and very similar amino acid sequences, they have different functions and are found in different locations. PONs exhibit substrate promiscuity, and their true physiological substrates are still not known. However, possible substrates include homocysteine thiolactone, an analogue of natural quorum-sensing molecules, and the recently discovered derivatives of arachidonic acid-bioactive δ-lactones. D

SUBMITTER: Taler-Vercic A 

PROVIDER: S-EPMC7766523 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature