Prognostic Value of the Diversity of Nuclear Chromatin Compartments in Gynaecological Carcinomas.

ABSTRACT: Statistical texture analysis of cancer cell nuclei stained for DNA has recently been used to develop a pan-cancer prognostic marker of chromatin heterogeneity. In this study, we instead analysed chromatin organisation by automatically quantifying the diversity of chromatin compartments in cancer cell nuclei. The aim was to investigate the prognostic value of such an assessment in relation to chromatin heterogeneity and as a potential supplement to pathological risk classifications in gynaecological carcinomas. The diversity was quantified by calculating the entropy of both chromatin compartment sizes and optical densities within compartments. We analysed a median of 281 nuclei (interquartile range (IQR), 273 to 289) from 246 ovarian carcinoma patients and a median of 997 nuclei (IQR, 502 t

SUBMITTER: Kleppe A 

PROVIDER: S-EPMC7766595 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature