Rapid Multianalyte Microfluidic Homogeneous Immunoassay on Electrokinetically Driven Beads.

ABSTRACT: The simplicity of homogeneous immunoassays makes them suitable for diagnostics of acute conditions. Indeed, the absence of washing steps reduces the binding reaction duration and favors a rapid and compact device, a critical asset for patients experiencing life-threatening diseases. In order to maximize analytical performance, standard systems employed in clinical laboratories rely largely on the use of high surface-to-volume ratio suspended moieties, such as microbeads, which provide at the same time a fast and efficient collection of analytes from the sample and controlled aggregation of collected material for improved readout. Here, we introduce an integrated microfluidic system that can perform analyte detection on antibody-decorated beads and their accumulation in confined regions wit

SUBMITTER: Thiriet PE 

PROVIDER: S-EPMC7766682 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature