The Genome-Wide Impact of Nipblb Loss-of-Function on Zebrafish Gene Expression.

ABSTRACT: Transcriptional changes normally occur during development but also underlie differences between healthy and pathological conditions. Transcription factors or chromatin modifiers are involved in orchestrating gene activity, such as the cohesin genes and their regulator NIPBL. In our previous studies, using a zebrafish model for nipblb knockdown, we described the effect of nipblb loss-of-function in specific contexts, such as central nervous system development and hematopoiesis. However, the genome-wide transcriptional impact of nipblb loss-of-function in zebrafish embryos at diverse developmental stages remains under investigation. By RNA-seq analyses in zebrafish embryos at 24 h post-fertilization, we examined genome-wide effects of nipblb knockdown on tr

SUBMITTER: Spreafico M 

PROVIDER: S-EPMC7766774 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature