Oral Microbiome Signatures in Hematological Cancers Reveal Predominance of Actinomyces and Rothia Species.

ABSTRACT: The endogenous microbiome of healthy individuals in oral cavities is diverse, representing over 700 bacterial species. Imbalance in oral and gut microbiome composition and associated gene expression has been linked to different forms of hematological (blood) cancers. Our objective is to compare oral microbiome profiles of patients with blood cancers (BC group: N = 39 patients, n = 124 oral samples) to those of healthy control subjects (HC group: N = 27 subjects, n = 100 oral samples). Saliva samples and swabs of buccal mucosa, supragingival plaque, and tongue were collected from blood cancer patients and healthy controls. Next-generation sequencing (16S-rRNA gene V3-V4 region) was used to determine the relative abundance of bacterial taxa present at the genus and species levels. Difference

SUBMITTER: Mougeot JC 

PROVIDER: S-EPMC7767039 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature