Nanobodies as Versatile Tool for Multiscale Imaging Modalities.

ABSTRACT: Molecular imaging is constantly growing in different areas of preclinical biomedical research. Several imaging methods have been developed and are continuously updated for both in vivo and in vitro applications, in order to increase the information about the structure, localization and function of molecules involved in physiology and disease. Along with these progresses, there is a continuous need for improving labeling strategies. In the last decades, the single domain antigen-binding fragments nanobodies (Nbs) emerged as important molecular imaging probes. Indeed, their small size (~15 kDa), high stability, affinity and modularity represent desirable features for imaging applications, providing higher tissue penetration, rapid targeting, increased spatial resolution and fast clearance. A

SUBMITTER: Erreni M 

PROVIDER: S-EPMC7767244 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature