Dark Matter of Primate Genomes: Satellite DNA Repeats and Their Evolutionary Dynamics.

ABSTRACT: A substantial portion of the primate genome is composed of non-coding regions, so-called "dark matter", which includes an abundance of tandemly repeated sequences called satellite DNA. Collectively known as the satellitome, this genomic component offers exciting evolutionary insights into aspects of primate genome biology that raise new questions and challenge existing paradigms. A complete human reference genome was recently reported with telomere-to-telomere human X chromosome assembly that resolved hundreds of dark regions, encompassing a 3.1 Mb centromeric satellite array that had not been identified previously. With the recent exponential increase in the availability of primate genomes, and the development of modern genomic and bioinformatics tools, extensive growth in our knowledge c

SUBMITTER: Ahmad SF 

PROVIDER: S-EPMC7767330 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature