Design and Implementation of NK Cell-Based Immunotherapy to Overcome the Solid Tumor Microenvironment.

ABSTRACT: Natural killer (NK) cells are innate immune effectors capable of broad cytotoxicity via germline-encoded receptors and can have conferred cytotoxic potential via the addition of chimeric antigen receptors. Combined with their reduced risk of graft-versus-host disease (GvHD) and cytokine release syndrome (CRS), NK cells are an attractive therapeutic platform. While significant progress has been made in treating hematological malignancies, challenges remain in using NK cell-based therapy to combat solid tumors due to their immunosuppressive tumor microenvironments (TMEs). The development of novel strategies enabling NK cells to resist the deleterious effects of the TME is critical to their therapeutic success against solid tumors. In this review, we discuss strategies that apply various gene

SUBMITTER: Navin I 

PROVIDER: S-EPMC7767468 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature