Ipriflavone-Loaded Mesoporous Nanospheres with Potential Applications for Periodontal Treatment.

ABSTRACT: The incorporation and effects of hollow mesoporous nanospheres in the system SiO2-CaO (nanoMBGs) containing ipriflavone (IP), a synthetic isoflavone that prevents osteoporosis, were evaluated. Due to their superior porosity and capability to host drugs, these nanoparticles are designed as a potential alternative to conventional bioactive glasses for the treatment of periodontal defects. To identify the endocytic mechanisms by which these nanospheres are incorporated within the MC3T3-E1 cells, five inhibitors (cytochalasin B, cytochalasin D, chlorpromazine, genistein and wortmannin) were used before the addition of these nanoparticles labeled with fluorescein isothiocyanate (FITC-nanoMBGs). The results indicate that nanoMBGs enter the pre-osteoblasts mainly through clathrin-dependent mechan

SUBMITTER: Casarrubios L 

PROVIDER: S-EPMC7767486 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature