Association of long noncoding RNA MALAT1 polymorphisms with gastric cancer risk in Korean individuals.

ABSTRACT:

Background

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) drives tumorigenesis of various human cancers. However, the association between MALAT1 variants and gastric cancer (GC) risk is unknown. We performed a case-control study to evaluate the possible association between rs619586 and rs3200401 SNPs in MALAT and GC risk.

Methods

Samples from 458 patients with GC and 381 controls were genotyped using the TaqMan genotyping assay.

Results

In stratified analyses, we observed that rs3200401 CT in the codominant model and CT+TT in the dominant model were associated with increased GC risk in male patients (CT: odds ratio [OR] = 1.81, 95% confidence interval [CI] = 1.09-3.01, p = 0.022; CT+TT: OR = 1.74, 95% CI = 1.07-2.83, p = 0.026), and the differentiated

SUBMITTER: Hong JH 

PROVIDER: S-EPMC7767557 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature