Genomic analysis of diet composition finds novel loci and associations with health and lifestyle.

ABSTRACT: We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P < 5 × 10^-8), while five of the 21 lead SNPs reach suggestive significance (P < 1 × 10^-5) for at least one other macronutrient. While the phenotypes are genetically correlated, each phenotype carries a partially unique genetic architecture. Relative protein intake exhibits the strongest relationships with poor health, including positive genetic associations with obesity, type 2 diabetes, and heart disease (r_g ≈ 0.15-0.5

SUBMITTER: Meddens SFW 

PROVIDER: S-EPMC7767645 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature