Suppression of ARID1A associated with decreased CD8 T cells improves cell survival of ovarian clear cell carcinoma.

ABSTRACT:

Objective

AT-rich interactive domain 1A (ARID1A) plays an important role as a tumor suppressor gene in ovarian clear cell carcinoma (OCCC), but the clinical application of ARID1A remains unclear. The aim of this study was to analyze clinicopathological parameters, molecular interactions and immune-infiltration in patients with low ARID1A expression and to provide candidate target drugs.

Methods

We investigated the clinicopathologic parameters, specific gene sets/genes, and immunological relevance according to ARID1A expression in 998 OCCC patients from 12 eligible studies (using meta-analyses); 30 OCCC patients from the Hanyang University Guri Hospital (HYGH) cohort; and 52 OCCC patients from gene set enrichment (GSE) 65986 (25 patients), 63885 (9 patients), and 54809 (6 pat

SUBMITTER: Jung US 

PROVIDER: S-EPMC7767648 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature