Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice.

ABSTRACT: Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as TNFalpha. We aimed to test a hypothesis that TTP in bone marrow (BM) cells regulates atherogenesis by modulating inflammation and lipid metabolism through the modulation of oxidative stress pathways by TTP target genes. In a BM transplantation study, lethally irradiated atherogenic LDLR^-/- mice were reconstituted with BM cells from either wild type (TTP^+/+) or TTP knockout (TTP^-/-) mice, and fed a Western diet for 12 weeks. We made the following observations: (1) TTP^-/- BM recipients display a significantly higher systemic and multi-organ inflammation than TTP^+/+ BM

SUBMITTER: Saaoud F 

PROVIDER: S-EPMC7767740 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature