Influenza A (H3) illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases.

ABSTRACT:

Background

It has long been known that nasal inoculation with influenza A virus produces asymptomatic to febrile infections. Uncertainty persists about whether these infections are sufficiently similar to natural infections for studying human-to-human transmission.

Methods

We compared influenza A viral aerosol shedding from volunteers nasally inoculated with A/Wisconsin/2005 (H3N2) and college community adults naturally infected with influenza A/H3N2 (2012-2013), selected for influenza-like illness with objectively measured fever or a positive Quidel QuickVue A&B test. Propensity scores were used to control for differences in symptom presentation observed between experimentally and naturally infected groups.

Results

Eleven (28%) experimental and 71 (86%) natural cases

SUBMITTER: Bueno de Mesquita PJ 

PROVIDER: S-EPMC7767952 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature