Generation of Thyroid Tissues From Embryonic Stem Cells via Blastocyst Complementation In Vivo.

ABSTRACT: The generation of mature, functional, thyroid follicular cells from pluripotent stem cells would potentially provide a therapeutic benefit for patients with hypothyroidism, but in vitro differentiation remains difficult. We earlier reported the in vivo generation of lung organs via blastocyst complementation in fibroblast growth factor 10 (Fgf10), compound, heterozygous mutant (Fgf10 Ex1^mut/Ex3^mut) mice. Fgf10 also plays an essential role in thyroid development and branching morphogenesis, but any role thereof in thyroid organogenesis remains unclear. Here, we report that the thyroids of Fgf10 Ex1^mut/Ex3^mut mice exhibit severe hypoplasia, and we generate thyroid tissues from mouse embryonic stem cells (ES

SUBMITTER: Ran Q 

PROVIDER: S-EPMC7767966 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature