Carnosic acid improves porcine early embryonic development by inhibiting the accumulation of reactive oxygen species.

ABSTRACT: Carnosic acid (CA), a natural catechol rosin diterpene, is used as an additive in animal feeds and human foods. However, the effects of CA on mammalian reproductive processes, especially early embryonic development, are unclear. In this study, we added CA to parthenogenetically activated porcine embryos in an in vitro culture medium to explore the influence of CA on apoptosis, proliferation, blastocyst formation, reactive oxygen species (ROS) levels, glutathione (GSH) levels, mitochondrial membrane potential, and embryonic development-related gene expression. The results showed that supplementation with 10 μM CA during in vitro culture significantly improved the cleavage rates, blastocyst formation rates, hatching rates, and total numbers of cells of parthenogenetically activated porcine e

SUBMITTER: Peng YX 

PROVIDER: S-EPMC7768177 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature