Inferring the Allelic Series at QTL in Multiparental Populations.

ABSTRACT: Multiparental populations (MPPs) are experimental populations in which the genome of every individual is a mosaic of known founder haplotypes. These populations are useful for detecting quantitative trait loci (QTL) because tests of association can leverage inferred founder haplotype descent. It is difficult, however, to determine how haplotypes at a locus group into distinct functional alleles, termed the allelic series. The allelic series is important because it provides information about the number of causal variants at a QTL and their combined effects. In this study, we introduce a fully Bayesian model selection framework for inferring the allelic series. This framework accounts for sources of uncertainty found in typical MPPs, including the number and composition of functional alleles

SUBMITTER: Crouse WL 

PROVIDER: S-EPMC7768242 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature