The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development.

ABSTRACT: Imaginal disc morphogenesis during metamorphosis in Drosophila melanogaster provides an excellent model to uncover molecular mechanisms by which hormonal signals effect physical changes during development. The broad (br) Z2 isoform encodes a transcription factor required for disc morphogenesis in response to 20-hydroxyecdysone, yet how it accomplishes this remains largely unknown. Here, we use functional studies of amorphic br⁵ mutants and a transcriptional target approach to identify processes driven by br and its regulatory targets in leg imaginal discs. br⁵ mutants fail to properly remodel their basal extracellular matrix (ECM) between 4 and 7 hr after puparium formation. Additionally, br

SUBMITTER: Rice C 

PROVIDER: S-EPMC7768262 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature