Regulatory Elements Inserted into AAVs Confer Preferential Activity in Cortical Interneurons.

ABSTRACT: Cortical interneuron (CIN) dysfunction is thought to play a major role in neuropsychiatric conditions like epilepsy, schizophrenia and autism. It is therefore essential to understand how the development, physiology, and functions of CINs influence cortical circuit activity and behavior in model organisms such as mice and primates. While transgenic driver lines are powerful tools for studying CINs in mice, this technology is limited in other species. An alternative approach is to use viral vectors such as AAV, which can be used in multiple species including primates and also have potential for therapeutic use in humans. Thus, we sought to discover gene regulatory enhancer elements (REs) that can be used in viral vectors to drive expression in specific cell types. The present study describes

SUBMITTER: Rubin AN 

PROVIDER: S-EPMC7768279 | biostudies-literature | 2020 Nov/Dec

REPOSITORIES: biostudies-literature