Atypical Cadherin FAT3 Is a Novel Mediator for Morphological Changes of Microglia.

ABSTRACT: Microglia are resident macrophages that are critical for brain development and homeostasis. Microglial morphology is dynamically changed during postnatal stages, leading to regulating synaptogenesis and synapse pruning. Moreover, it has been well known that the shape of microglia is also altered in response to the detritus of the apoptotic cells and pathogens such as bacteria and viruses. Although the morphologic changes are crucial for acquiring microglial functions, the exact mechanism which controls their morphology is not fully understood. Here, we report that the FAT atypical cadherin family protein, FAT3, regulates the morphology of microglial cell line, BV2. We found that the shape of BV2 becomes elongated in a high-nutrient medium. Using microarray analysis, we identified that FAT3

SUBMITTER: Okajima T 

PROVIDER: S-EPMC7768282 | biostudies-literature | 2020 Nov/Dec

REPOSITORIES: biostudies-literature