Mud Loss Restricts Yki-Dependent Hyperplasia in Drosophila Epithelia.

ABSTRACT: Tissue development demands precise control of cell proliferation and organization, which is achieved through multiple conserved signaling pathways and protein complexes in multicellular animals. Epithelia are a ubiquitous tissue type that provide diverse functions including physical protection, barrier formation, chemical exchange, and secretory activity. However, epithelial cells are also a common driver of tumorigenesis; thus, understanding the molecular mechanisms that control their growth dynamics is important in understanding not only developmental mechanisms but also disease. One prominent pathway that regulates epithelial growth is the conserved Hippo/Warts/Yorkie network. Hippo/Warts inactivation, or activating mutations in Yorkie that prevent its phosphorylation (e.g., Yki^S16

SUBMITTER: Parra AS 

PROVIDER: S-EPMC7768408 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature