Comparative Immunological Study in Mice of Inactivated Influenza Vaccines Used in the Russian Immunization Program.

ABSTRACT: A series of commercial inactivated influenza vaccines (IIVs) used in the Russian National Immunization Program were characterized to evaluate their protective properties on an animal model. Standard methods for quantifying immune response, such as hemagglutination inhibition (HAI) assay and virus neutralization (VN) assay, allowed us to distinguish the immunogenic effect of various IIVs from that of placebo. However, these standard approaches are not suitable to determine the role of various vaccine components in immune response maturation. The expanded methodological base including an enzyme-linked immunosorbent assay (ELISA) and a neuraminidase ELISA (NA-ELISA) helped us to get wider characteristics and identify the effectiveness of various commercial vaccines depending on the antigen co

SUBMITTER: Shanko A 

PROVIDER: S-EPMC7768547 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature