Effect of APOE ε4 on multimodal brain connectomic traits: a persistent homology study.

ABSTRACT:

Background

Although genetic risk factors and network-level neuroimaging abnormalities have shown effects on cognitive performance and brain atrophy in Alzheimer's disease (AD), little is understood about how apolipoprotein E (APOE) ε4 allele, the best-known genetic risk for AD, affect brain connectivity before the onset of symptomatic AD. This study aims to investigate APOE ε4 effects on brain connectivity from the perspective of multimodal connectome.

Results

Here, we propose a novel multimodal brain network modeling framework and a network quantification method based on persistent homology for identifying APOE ε4-related network differences. Specifically, we employ sparse representation to integrate multimodal brain network information derived from both the resting state f

SUBMITTER: Li J 

PROVIDER: S-EPMC7768655 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature