The porphyrin ring rather than the metal ion dictates long-range electron transport across proteins suggesting coherence-assisted mechanism.

ABSTRACT: The fundamental biological process of electron transfer (ET) takes place across proteins with common ET pathways of several nanometers. Recent discoveries push this limit and show long-range extracellular ET over several micrometers. Here, we aim in deciphering how protein-bound intramolecular cofactors can facilitate such long-range ET. In contrast to natural systems, our protein-based platform enables us to modulate important factors associated with ET in a facile manner, such as the type of the cofactor and its quantity within the protein. We choose here the biologically relevant protoporphyrin molecule as the electron mediator. Unlike natural systems having only Fe-containing protoporphyrins, i.e., heme, as electron mediators, we use here porphyrins with different metal centers, or lac

SUBMITTER: Agam Y 

PROVIDER: S-EPMC7768700 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature