A Novel Approach to Developing a Discordance Index for Older Adults With Chronic Kidney Disease.

ABSTRACT:

Background

Older adults with chronic kidney disease (CKD)-discordant conditions (comorbid conditions with treatment recommendations that potentially complicate CKD management) have higher risk of hospitalization and death. Our goal is to develop a CKD-Discordance Index using electronic health records to improve recognition of discordance.

Methods

This retrospective cohort study included Kaiser Permanente Southern California patients aged ≥65 years and older with incident CKD (N = 30,932). To guide inclusion of conditions in the Index and weight each condition, we first developed a prediction model for 1-year hospitalization risk using Cox regression. Points were assigned proportional to regression coefficients derived from the model. Next, the CKD-Discordance Index was calcu

SUBMITTER: Hall RK 

PROVIDER: S-EPMC7768728 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature