Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data.

ABSTRACT:

Background

Pneumococcal conjugate vaccines (PCVs) have reduced pneumococcal diseases globally. Pneumococcal genomic surveys elucidate PCV effects on population structure but are rarely conducted in low-income settings despite the high disease burden.

Methods

We undertook whole-genome sequencing (WGS) of 660 pneumococcal isolates collected through surveys from healthy carriers 2 years from 13-valent PCV (PCV13) introduction and 1 year after rollout in northern Malawi. We investigated changes in population structure, within-lineage serotype dynamics, serotype diversity, and frequency of antibiotic resistance (ABR) and accessory genes.

Results

In children <5 years of age, frequency and diversity of vaccine serotypes (VTs) decreased significantly post-PCV, but no signific

SUBMITTER: Chaguza C 

PROVIDER: S-EPMC7768739 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature