A comprehensive analysis of microRNAs as diagnostic biomarkers for asthma.

ABSTRACT:

Background

It is unclear whether microRNAs could be a potential diagnostic biomarker for asthma or not. The objective of this study is to figure out the diagnostic value of microRNAs in asthma.

Methods

Literature retrieval, screening of publications, specific data extraction, and quality evaluation were conducted according to the standard criteria. Stata 14.0 software was used to analyze the diagnostic value of microRNA for asthma, including the combined sensitivity (Sen), specificity (Spe), the area under the curve (AUC), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR).

Results

A total of 72 studies, containing 4143 cases and 2188 controls, were included for this comprehensive analysis. None of the included publicatio

SUBMITTER: Xu L 

PROVIDER: S-EPMC7768876 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature