Inflammation and hypertension development: A longitudinal analysis of the African-PREDICT study.

ABSTRACT:

Background

The role of inflammation in the development of hypertension remains incompletely understood. While single inflammatory mediators have been shown to associate with changes in blood pressure (ΔBP), the role of clusters of inflammatory mediators has been less comprehensively explored. We therefore determined whether individual or clusters of inflammatory mediators from a large biomarker panel were associated with ΔBP over 4.5 years, in young healthy adults.

Methods

We included 358 adults (white, n = 156; black, n = 202) with detailed information on ambulatory blood pressure (BP) at baseline and follow-up. Baseline blood samples were analysed for 22 inflammatory mediators using multiplexing technology. Principal component analysis was used to study associations betwee

SUBMITTER: Crouch SH 

PROVIDER: S-EPMC7768897 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature