Animal Models of Cancer-Related Pain: Current Perspectives in Translation.

ABSTRACT: The incidence of pain in cancer patients during diagnosis and treatment is exceedingly high. Although advances in cancer detection and therapy have improved patient prognosis, cancer and its treatment-associated pain have gained clinical prominence. The biological mechanisms involved in cancer-related pain are multifactorial; different processes for pain may be responsible depending on the type and anatomic location of cancer. Animal models of cancer-related pain have provided mechanistic insights into the development and process of pain under a dynamic molecular environment. However, while cancer-evoked nociceptive responses in animals reflect some of the patients' symptoms, the current models have failed to address the complexity of interactions within the natural disease state. Although

SUBMITTER: Pineda-Farias JB 

PROVIDER: S-EPMC7768910 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature