Cardiovascular Toxicity of Targeted Therapies for Cancer: An Overview of Systematic Reviews.

ABSTRACT:

Background

Several targeted therapies for cancer have been associated with cardiovascular toxicity. The evidence for this association has not been synthesized systematically nor has the quality of evidence been considered. We synthesized systematic review evidence of cardiovascular toxicity of individual targeted agents.

Methods

We searched MEDLINE, Embase, and the Cochrane Database of Systematic Reviews for systematic reviews with meta-analyses of cardiovascular outcomes for individual agents published to May 2020. We selected reviews according to prespecified eligibility criteria (International Prospective Register of Systematic Reviews CRD42017080014). We classified evidence of cardiovascular toxicity as sufficient, probable, possible, or indeterminate for specific cardio

SUBMITTER: Van Leeuwen MT 

PROVIDER: S-EPMC7768929 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature