Case-control study of nutritional and environmental factors and the risk of oral clefts in Thailand.

ABSTRACT:

Background

One infant in 700 is born with an oral cleft. Prior studies suggest low micronutrient status is associated with an increased risk of oral clefts. Environmental factors such as passive smoke exposure or supplement use may also affect oral cleft risk. We examined nutrition and environmental related risk factors for oral clefts.

Methods

We conducted a case-control study in Northeast Thailand in 2012 to 2013. We enrolled 95 cases and 95 controls. We recruited cases with a nonsyndromic cleft lip with or without a cleft palate (CL±P) less than 24 months old. Cases were matched to controls on age and place of conception. We collected survey data, a food frequency questionnaire, and measured zinc concentrations in toenail trimmings. We calculated descriptive statistics by

SUBMITTER: McKinney CM 

PROVIDER: S-EPMC7769134 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature