Shared genetic etiology underlying late-onset Alzheimer's disease and posttraumatic stress syndrome.

ABSTRACT:

Introduction

Late-onset Alzheimer's disease (LOAD) manifests comorbid neuropsychiatric symptoms and posttraumatic stress disorder (PTSD) is associated with an increased risk for dementia in late life, suggesting the two disorders may share genetic etiologies.

Methods

We performed genetic pleiotropy analysis using LOAD and PTSD genome-wide association study (GWAS) datasets from white and African-American populations, followed by functional-genomic analyses.

Results

We found an enrichment for LOAD across increasingly stringent levels of significance with the PTSD GWAS association (LOAD|PTSD) in the discovery and replication cohorts and a modest enrichment for the reverse conditional association (PTSD|LOAD). LOAD|PTSD association analysis identified and replicated the MS

SUBMITTER: Lutz MW 

PROVIDER: S-EPMC7769164 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature