Pravastatin-induced changes in expression of long non-coding and coding RNAs in endothelial cells.

ABSTRACT:

Objective

Atherosclerosis is the main cause of the cardiovascular disease (CVD). Elevated blood cholesterol and inflammation of the endothelium are two major mechanisms contributing to the establishment of atherosclerotic plaques. Statins, such as pravastatin, are blood-cholesterol lowering drugs commonly prescribed for patients with or at risk for CVDs. In addition to lowering blood cholesterols, statins have recently been shown to improve endothelial function in both hyper- and normocholesterolemic patients with atherosclerosis. To understand the molecular mechanisms underlying the endothelial function improvement by statins, we assessed the RNA profile of pravastatin-treated endothelial cells, particularly their mRNAs and long non-coding RNAs (lncRNAs).

Methods

Human umbi

SUBMITTER: Singh S 

PROVIDER: S-EPMC7769171 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature