Targeting Tumor-Associated Macrophages in the Pediatric Sarcoma Tumor Microenvironment.

ABSTRACT: For many pediatric sarcoma patients, multi-modal therapy including chemotherapy, radiation, and surgery is sufficient to cure their disease. However, event-free and overall survival rates for patients with more advanced disease are grim, necessitating the development of novel therapeutic approaches. Within many pediatric sarcomas, the normal immune response, including recognition and destruction of cancer cells, is lost due to the highly immune suppressive tumor microenvironment (TME). In this setting, tumor cells evade immune detection and capitalize on the immune suppressed microenvironment, leading to unchecked proliferation and metastasis. Recent preclinical and clinical approaches are aimed at understanding this immune suppressive microenvironment and employing cancer immunotherapy in

SUBMITTER: Koo J 

PROVIDER: S-EPMC7769312 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature