Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease.

ABSTRACT:

Background

Chronic kidney disease (CKD) is associated with an elevated risk of all-cause mortality, with cardiovascular death being extensively investigated. However, non-cardiovascular mortality represents the biggest percentage, showing an evident increase in recent years. Klotho is a gene highly expressed in the kidney, with a clear influence on lifespan. Low levels of Klotho have been linked to CKD progression and adverse outcomes. Single nucleotide polymorphisms (SNPs) of the Klotho gene have been associated with several diseases, but studies investigating the association of Klotho SNPs with non-cardiovascular death in CKD populations are lacking.

Methods

The main aim of this study was to assess whether 11 Klotho SNPs were associated with non-cardiovascular death in a s

SUBMITTER: Cambray S 

PROVIDER: S-EPMC7769551 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature