Transthyretin amyloid cardiomyopathy in women: frequency, characteristics, and diagnostic challenges.

ABSTRACT: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive, life-threatening disease characterized by deposition of insoluble amyloid fibrils in the myocardium, resulting in cardiac structural and functional abnormalities and ultimately heart failure. Disease frequency is reportedly lower in women than men, but sex-related differences have not been well established. We conducted a systematic literature review (SLR), based on PRISMA-P guidelines and registered with PROSPERO, to assess whether the epidemiology and clinical presentation of ATTR-CM differ between women and men. MEDLINE, Embase, and Cochrane databases and selected conference proceedings were searched (August 16, 2019) to identify observational and clinical studies reporting sex-specific data for patients with wild-type or

SUBMITTER: Bruno M 

PROVIDER: S-EPMC7769788 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature