Organometallic Complex Strongly Impairs Chikungunya Virus Entry to the Host Cells.

ABSTRACT: Chikungunya fever is a disease caused by the Chikungunya virus (CHIKV) that is transmitted by the bite of the female of Aedes sp. mosquito. The symptoms include fever, muscle aches, skin rash, and severe joint pains. The disease may develop into a chronic condition and joint pain for months or years. Currently, there is no effective antiviral treatment against CHIKV infection. Treatments based on natural compounds have been widely studied, as many drugs were produced by using natural molecules and their derivatives. Alpha-phellandrene (α-Phe) is a naturally occurring organic compound that is a ligand for ruthenium, forming the organometallic complex [Ru₂Cl₄(p-cymene)₂] (RcP). Organometallic complexes have shown promising as candidate molecules to a n

SUBMITTER: de Oliveira DM 

PROVIDER: S-EPMC7769844 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature