The evolution of parkinsonism in primary progressive apraxia of speech: A 6-year longitudinal study.

ABSTRACT:

Introduction

Primary progressive apraxia of speech (PPAOS) is a neurodegenerative syndrome in which patients present with an isolated motor speech disorder. Some PPAOS patients develop parkinsonism and other features of progressive supranuclear palsy (PSP) and/or corticobasal syndrome (CBS) over time. We aimed to assess the evolution of parkinsonian characteristics in PPAOS patients who had been followed yearly for at least six years.

Methods

From a large cohort of 46 PPAOS patients, eight were followed yearly for > 6-years in multiple NIH-funded grants. Parkinsonian and other features, including bradykinesia, tremor, rigidity, postural instability, apraxia, ocular motor function and cognition were assessed at each visit, and research criteria applied for PSP and CBS diagnos

SUBMITTER: Seckin ZI 

PROVIDER: S-EPMC7769910 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature