Genome-Wide Association Study Highlights <i>APOH</i> as a Novel Locus for Lipoprotein(a) Levels-Brief Report.

ABSTRACT:

Objective

Lp(a) (lipoprotein[a]) is an independent risk factor for cardiovascular diseases and plasma levels are primarily determined by variation at the LPA locus. We performed a genome-wide association study in the UK Biobank to determine whether additional loci influence Lp(a) levels. Approach and Results: We included 293 274 White British individuals in the discovery analysis. Approximately 93 095 623 variants were tested for association with natural log-transformed Lp(a) levels using linear regression models adjusted for age, sex, genotype batch, and 20 principal components of genetic ancestry. After quality control, 131 independent variants were associated at genome-wide significance (P≤5×10^-8). In addition to validating previous associations at LP

SUBMITTER: Hoekstra M 

PROVIDER: S-EPMC7769958 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature