Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice.

ABSTRACT: Bone is a dynamic organ that is continuously modified during development, load-induced adaptation, and fracture repair. Understanding the cellular and molecular mechanisms for natural fracture healing can lead to therapeutics that enhance the quality of newly formed tissue, advance the rate of healing, or replace the need for invasive surgical procedures. Prx1-expressing cells in the periosteum are thought to supply the majority of osteoblasts and chondrocytes in the fracture callus, but the exact mechanisms for this behavior are unknown. The primary cilium is a sensory organelle that is known to mediate several signaling pathways involved in fracture healing and required for Prx1-expressing cells to contribute to juvenile bone development and adult load-induced bone formation. We therefor

SUBMITTER: Moore ER 

PROVIDER: S-EPMC7769995 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature