Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination.

ABSTRACT: The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters play important roles in the disposition of clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins, and therefore critical for maintaining systemic homeostasis. Alterations in the expression and function of OATs contribute to the intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs, and to many pathophysiological conditions. Consequently, the activity of these transporters must be highly regulated to carry out their normal functions. This review will present an update on the recent advance in understanding the cellular and molecular mechanism

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7770002 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature