Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.

ABSTRACT: Despite its success in achieving the long-term survival of 10-30% of treated individuals, immune therapy is still ineffective for most patients with cancer^1,2. Many efforts are therefore underway to identify new approaches that enhance such immune 'checkpoint' therapy^3-5 (so called because its aim is to block proteins that inhibit checkpoint signalling pathways in T cells, thereby freeing those immune cells to target cancer cells). Here we show that inhibiting PCSK9-a key protein in the regulation of cholesterol metabolism^6-8-can boost the response of tumours to immune checkpoint therapy, through a mechanism that is independent of PCSK9's cholesterol-regulating functions. Deleting the PCSK9 gene in mouse cancer cells substantially attenuates or prevents the

SUBMITTER: Liu X 

PROVIDER: S-EPMC7770056 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature