Analyzing left-truncated and right-censored infectious disease cohort data with interval-censored infection onset.

ABSTRACT: In an infectious disease cohort study, individuals who have been infected with a pathogen are often recruited for follow up. The period between infection and the onset of symptomatic disease, referred to as the incubation period, is of interest because of its importance on disease surveillance and control. However, the incubation period is often difficult to ascertain due to the uncertainty associated with asymptomatic infection onset time. An additional complication is that the observed infected subjects are likely to have longer incubation periods due to the prevalent sampling. In this article, we demonstrate how to estimate the distribution of the incubation period with the uncertain infection onset, subject to left-truncation and right-censoring. We employ a family of sufficiently gene

SUBMITTER: Pak D 

PROVIDER: S-EPMC7770078 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature