The effect of airway motion and breathing phase during imaging on CFD simulations of respiratory airflow.

ABSTRACT:

Rationale

Computational fluid dynamics (CFD) simulations of respiratory airflow can quantify clinically useful information that cannot be obtained directly, such as the work of breathing (WOB), resistance to airflow, and pressure loss. However, patient-specific CFD simulations are often based on medical imaging that does not capture airway motion and thus may not represent true physiology, directly affecting those measurements.

Objectives

To quantify the variation of respiratory airflow metrics obtained from static models of airway anatomy at several respiratory phases, temporally averaged airway anatomies, and dynamic models that incorporate physiological motion.

Methods

Neonatal airway images were acquired during free-breathing using 3D high-resolution MRI and recon

SUBMITTER: Gunatilaka CC 

PROVIDER: S-EPMC7770091 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature