Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction.

ABSTRACT:

Objective

The platelet phenotype in certain patients and clinical contexts may differ from healthy conditions. We evaluated platelet activation through specific receptors in healthy men and women, comparing this to patients presenting with ST-segment-elevation myocardial infarction and non-ST-segment-elevation myocardial infarction. Approach and Results: We identified independent predictors of platelet activation through certain receptors and a murine MI model further explored these findings. Platelets from healthy women and female mice are more reactive through PARs (protease-activated receptors) compared with platelets from men and male mice. Multivariate regression analyses revealed male sex and non-ST-segment-elevation myocardial infarction as independent predictors of enhanced

SUBMITTER: Soo Kim B 

PROVIDER: S-EPMC7770120 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature