Lymphoangiocrine signals promote cardiac growth and repair.

ABSTRACT: Recent studies have suggested that lymphatics help to restore heart function after cardiac injury^1-6. Here we report that lymphatics promote cardiac growth, repair and cardioprotection in mice. We show that a lymphoangiocrine signal produced by lymphatic endothelial cells (LECs) controls the proliferation and survival of cardiomyocytes during heart development, improves neonatal cardiac regeneration and is cardioprotective after myocardial infarction. Embryos that lack LECs develop smaller hearts as a consequence of reduced cardiomyocyte proliferation and increased cardiomyocyte apoptosis. Culturing primary mouse cardiomyocytes in LEC-conditioned medium increases cardiomyocyte proliferation and survival, which indicates that LECs produce lymphoangiocrine signals that control car

SUBMITTER: Liu X 

PROVIDER: S-EPMC7770123 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature