Posterior Cingulate Cortex Network Predicts Alzheimer's Disease Progression.

ABSTRACT: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of toxic misfolded proteins, which are believed to have propagated from disease-specific epicenters through their corresponding large-scale structural networks in the brain. Although previous cross-sectional studies have identified potential AD-associated epicenters and corresponding brain networks, it is unclear whether these networks are associated with disease progression. Hence, this study aims to identify the most vulnerable epicenters and corresponding large-scale structural networks involved in the early stages of AD and to evaluate its associations with multiple cognitive domains using longitudinal study design. Annual neuropsychological and MRI assessments were obtained from 23 p

SUBMITTER: Lee PL 

PROVIDER: S-EPMC7770227 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature