The combination of dibenzazepine and a DOT1L inhibitor enables a stable maintenance of human naive-state pluripotency in non-hypoxic conditions.

ABSTRACT: Conventional human pluripotent stem cells (hPSCs), known for being in a primed state, are pivotal for both basic research and clinical applications since such cells produce various types of differentiated cells. Recent reports on PSCs shed light on the pluripotent hierarchy of stem cells and have promoted the exploration of new stem cell states along with their culture systems. Human naïve PSCs are expected to provide further knowledge of early developmental mechanisms and improvements for differentiation programmes in the regenerative therapy of conventionally primed PSCs. However, practical challenges exist in using naïve-state PSCs such as determining the conditions for hypoxic culture condition and showing limited stable cellular proliferation. Here, we have developed new leukemia inhi

SUBMITTER: Isono W 

PROVIDER: S-EPMC7770342 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature