Manganese nanodepot augments host immune response against coronavirus.

ABSTRACT: Interferon (IFN) responses are central to host defense against coronavirus and other virus infections. Manganese (Mn) is capable of inducing IFN production, but its applications are limited by nonspecific distributions and neurotoxicity. Here, we exploit chemical engineering strategy to fabricate a nanodepot of manganese (nanoMn) based on Mn²⁺. Compared with free Mn²⁺, nanoMn enhances cellular uptake and persistent release of Mn²⁺ in a pH-sensitive manner, thus strengthening IFN response and eliciting broad-spectrum antiviral effects in vitro and in vivo. Preferentially phagocytosed by macrophages, nanoMn promotes M1 macrophage polarization and recruits monocytes into inflammatory foci, eventually augmenting antiviral immunity and ameliorating

SUBMITTER: Sun Y 

PROVIDER: S-EPMC7770383 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature